Moclobemide

SIGMA/M3071 - ≥98% (HPLC), solid

Synonym: 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide; Aurorix; Moclamine

CAS Number: 71320-77-9
Empirical Formula (Hill Notation): C₁₃H₁₇ClN₂O₂
Molecular Weight: 268.74
MDL Number: MFCD00865388
Linear Formula: C₁₃H₁₇ClN₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M3071-10MG	10 mg	$196.00 1/EA		Add To Favorites
45-M3071-50MG	50 mg	$779.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
InChI key	YHXISWVBGDMDLQ-UHFFFAOYSA-N
originator	Roche
Quality Level	100
SMILES string	Clc1ccc(cc1)C(=O)NCCN2CCOCC2
solubility	DMSO: >20 mg/mL
storage temp.	room temp

Biochem/physiol Actions:	Moclobemide acts as a substrate for cytochrome P450 2C19 (CYP2C19). It also behaves as an inhibitor of cytochrome P450 2D6 (CYP2D6), cytochrome P450 1A2 (CYP1A2 and CYP2C19. Moclobemide is also involved in the increased expression of B-cell lymphoma 2 (BcL-2). It also causes neural stem cell (NSC) differentiation into serotoninergic neuron by extracellular‐regulated kinase (ERK) pathway.
Biochem/physiol Actions:	Moclobemide is a reversible monoamine oxidase A inhibitor (MAOI); antidepressant.
Biochem/physiol Actions:	Moclobemide is a reversible monoamine oxidase A inhibitor (MAOI); antidepressant. Elimination half-life in humans = 1 -3 hrs; absolute oral bioavailability. Unlike other MAO inhibitors, does not significantly increase blood pressure in humans upon combination with tyramine.
Features and Benefits:	This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS05,GHS07
Signal word	Danger
Hazard statements	H302 - H315 - H318 - H335
Precautionary statements	P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
Hazard Codes	Xn
Risk Statements	22-37/38-41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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