MJ33 lithium salt
SIGMA/M3315 - powder, ≥90% (NMR)
Synonym: 1-
CAS Number: 199106-13-3
Empirical Formula (Hill Notation): C22H43F3O6PLi
Molecular Weight: 498.48
MDL Number: MFCD03787978
Linear Formula: C22H43F3O6PLi
Product Type: Chemical
| assay | ≥90% (NMR) |
| color | white to beige |
| form | powder |
| InChI | 1S/C22H44F3O6P.Li/c1-3-4- |
| InChI key | GDLMLQJISATCEL-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CCCCCCCCCCCCCCCCOCC(COCC( |
| solubility | H2O: ≥5 mg/mL (warmed at 60 °C) |
| storage temp. | 2-8°C |
| Application: | MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor: • to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates • to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia • to study its potential use as a therapeutic agent |
| Biochem/physiol Actions: | MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate. |
| Biochem/physiol Actions: | Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A2 (PLA2). |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (NMR) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41106300 |