Magnolol
SIGMA/M3445 - ≥90% (HPLC), from plant
Synonym: 2,2′-Bichavicol; 5,5′-Diallyl-2,2′-biphenyldiol
CAS Number: 528-43-8
Empirical Formula (Hill Notation): C18H18O2
Molecular Weight: 266.33
MDL Number: MFCD00016658
Linear Formula: C18H18O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M3445-10MG
| antibiotic activity spectrum | fungi |
| Gram-negative bacteria | |
| Gram-positive bacteria | |
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥90% (HPLC) |
| biological source | plant |
| InChI | 1S/C18H18O2/c1-3-5-13-7-9 |
| InChI key | VVOAZFWZEDHOOU-UHFFFAOYSA |
| mode of action | cell membrane | interferes |
| Quality Level | 200  |
| SMILES string | Oc1ccc(CC=C)cc1-c2cc(CC=C |
| solubility | ethanol: soluble 1 mg/mL |
| methanol: soluble 1.5 mg/mL | |
| storage temp. | 2-8°C |
| Application: | Magnolol has been used: • to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model • to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay • to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains • in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies |
| Biochem/physiol Actions: | Magnolol exerts anti-depressant and, neurodegenerative properties. It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis. |
| Biochem/physiol Actions: | Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation. |
| General description: | Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees. It has a hydroxylated bi-phenoid structure like that of its structural isomer honokiol. It is a lipophilic compound. |
| Packaging: | 10 mg in glass bottle |
| Symbol |    GHS05,GHS07,GHS09 |
| Signal word | Danger |
| Hazard statements | H315 - H318 - H335 - H411 |
| Precautionary statements | P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Codes | N |
| Risk Statements | 37/38-41-51/53 |
| Safety Statements | 26-39-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥90% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352100 |