β,γ-Methyleneguanosine 5′-triphosphate sodium salt

SIGMA/M3509 - ≥98% (HPLC)

Synonym: GMPPCP; GppCp; Guanosine-5′-[(β,γ)-methyleno]triphosphate sodium salt

CAS Number: 10470-57-2
Empirical Formula (Hill Notation): C₁₁H₁₈N₅O₁₃P₃ · xNa⁺
Molecular Weight: 521.21 (free acid basis)
MDL Number: MFCD00070117
Linear Formula: C₁₁H₁₈N₅O₁₃P₃ · xNa⁺
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M3509-25MG	25 mg	$293.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	powder
InChI	1S/C11H18N5O13P3.Na.H/c12-11-14-8-5(9(19)15-11)13-2-16(8)10-7(18)6(17)4(28-10)1-27-32(25,26)29-31(23,24)3-30(20,21)22;;/h2,4,6-7,10,17-18H,1,3H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19);;
InChI key	LJQPGKRRFLMZPX-UHFFFAOYSA-N
Quality Level	200
SMILES string	[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(=O)CP(O)(O)=O)C(O)C3O)c2N1
solubility	water: 50 mg/mL, clear, colorless
storage temp.	−20°C

Application:	βγ-Methyleneguanosine 5′-triphosphate (GMPPCP, GppCp) is a non-hydrolyzable analog of GTP used in a variety of applications that involve GTP binding including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis and GTP structure stabilization. GMPPCP (GuoPP[CH₂MP) is used to modulate and study G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Application:	β,γ-Methyleneguanosine 5′-triphosphate sodium salt has been used as a GTP analog to complex with dynamin for cryo-electron microscopy studies. It has also been used to complex with Di-Ras1/Di-Ras2 and nucleotide exchange delivery studies.
Biochem/physiol Actions:	βγ-Methyleneguanosine 5′-triphosphate (GMPPCP) is used in a variety of applications that involve GTP binding including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis and GTP structure stabilization. GMPPCP is used to modulate and study G proteins involved in cell signaling, protein synthesis and other metabolic processes.
General description:	βγ-Methyleneguanosine 5′-triphosphate (GMPPCP, GppCp) is a non-hydrolyzable analog of GTP.
Packaging:	25 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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