Mycophenolic acid
SIGMA/M3536 - powder, BioReagent, suitable for cell culture
Synonym: 6-
CAS Number: 24280-93-1
Empirical Formula (Hill Notation): C17H20O6
Molecular Weight: 320.34
EC Number: 246-119-3
MDL Number: MFCD00036814
Linear Formula: C17H20O6
Product Type: Chemical
| biological source | Penicillium brevicompactum |
| color | white to yellow-white |
| form | powder |
| InChI | 1S/C17H20O6/c1-9(5-7-13(1 |
| InChI key | HPNSFSBZBAHARI-RUDMXATFSA |
| mode of action | enzyme | inhibits |
| mp | <143.0 °C |
| product line | BioReagent |
| Quality Level | 300  |
| SMILES string | COc1c(C)c2COC(=O)c2c(O)c1 |
| solubility | methanol: 50 mg/mL |
| storage temp. | 2-8°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL. |
| Biochem/physiol Actions: | Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase. |
| Disclaimer: | As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly. |
| Packaging: | 50, 250 mg in serum bottle |
| Preparation Note: | Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C. |
| Symbol |    GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H302 - H341 - H360D - H372 - H410 |
| Precautionary statements | P201 - P273 - P301 + P312 + P330 - P308 + P313 |
| Hazard Codes | T,N |
| Risk Statements | 61-22-48/25-50/53-68 |
| Safety Statements | 53-22-45-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | <143.0 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352207 |