Synonym: N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
CAS Number: 368449-04-1
Empirical Formula (Hill Notation): C20H16N2O6
Molecular Weight: 380.35
MDL Number: MFCD24368986
Linear Formula: C20H16N2O6
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
off-white to light tan |
| form |
powder |
| InChI |
1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28) |
| InChI key |
MIQUEZGHEJGPJB-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O |
| solubility |
DMSO: ≥20 mg/mL |
| storage temp. |
2-8°C |
| Application: |
MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast. |
| Biochem/physiol Actions: |
MST-312 is a telomerase Inhibitor. |
| Biochem/physiol Actions: |
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells. |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard Codes |
N |
| Risk Statements |
50 |
| Safety Statements |
61 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
