Malonyl coenzyme A lithium salt

SIGMA/M4263 - ≥90% (HPLC)

Synonym: Malonyl CoA lithium salt

CAS Number: 108347-84-8
Empirical Formula (Hill Notation): C₂₄H₃₈N₇O₁₉P₃S · xLi⁺
Molecular Weight: 853.58 (free acid basis)
Linear Formula: C₂₄H₃₈N₇O₁₉P₃S · xLi⁺
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M4263-5MG	5 mg	$165.00 1/EA	Add To Favorites
45-M4263-10MG	10 mg	$316.00 1/EA	Add To Favorites
45-M4263-25MG	25 mg	$633.00 1/EA	Add To Favorites
45-M4263-100MG	100 mg	$2010.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
InChI	1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);
InChI key	OPIJLICRFQMMJH-UHFFFAOYSA-N
Quality Level	200
SMILES string	[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
solubility	H₂O: soluble 50 mg/mL protein, clear, colorless
storage temp.	−20°C

Application:	Malonyl coenzyme A lithium salt has been used: • in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay • in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase • as an internal standard in the reaction mixture used for succinyl-CoA ligase assay
Biochem/physiol Actions:	Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
Biochem/physiol Actions:	Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.
Packaging:	5, 10, 25, 100 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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