Mefenamic acid
SIGMA/M4267
Synonym: 2-
CAS Number: 61-68-7
Empirical Formula (Hill Notation): C15H15NO2
Molecular Weight: 241.29
EC Number: 200-513-1
MDL Number: MFCD00051721
Linear Formula: C15H15NO2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M4267-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M4267-50G
| InChI | 1S/C15H15NO2/c1-10-6-5-9- |
| InChI key | HYYBABOKPJLUIN-UHFFFAOYSA |
| originator | Shionogi |
| Quality Level | 100  |
| SMILES string | Cc1cccc(Nc2ccccc2C(O)=O)c |
| Application: | An NSAID. Circumvents MRP-mediated multidrug resistance. Specifically and significantly potentiates the cytotoxicity of anthracyclines as well as teniposide, VP-16 and vincristine. |
| Application: | Mefenamic acid has been used: • to test its hepatotoxic effect in the transgenic zebrafish cell line (LiPan) • to test its neuroprotective functionality in zebrafish embryos/larvae • in the preparation of mucoadhesive microparticles in hydrogel beads |
| Biochem/physiol Actions: | Mefenamic acid is an analgesic and anti-inflammatory drug. It acts as a cyclooxygenase (COX) enzyme inhibitor. It is hepatoxic and implicated in liver injury. Contrarily, mefenamic acid elicits neuroprotection in in vivo ischemic stroke models by inhibiting cell toxicity induced by glutamate. Mefenamic due its inhibitory effect on prostaglandin synthesis can be used in reducing edema and ache. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Shionogi . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 50, 500 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12161501 |