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Meclofenamic acid sodium salt

SIGMA/M4531

Synonym: 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt

CAS Number: 6385-02-0
Empirical Formula (Hill Notation): C14H10Cl2NNaO2
Molecular Weight: 318.13
EC Number: 228-983-3
MDL Number: MFCD00077376
Linear Formula: C14H10Cl2NO2Na
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M4531-5G 5 g
 $218.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M4531-1G

 

assay ≥93% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
InChI key CHGIZYUDGOIAFY-UHFFFAOYSA-N
Quality Level 100 
SMILES string [Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
solubility water: 50 mg/mL, clear, colorless to faintly brownish-yellow
  water: 50 mg/mL, clear, colorless to faintly yellow
  water: 50 mg/mL, clear, colorless to very faintly brown
Application: Meclofenamic acid sodium salt has been used:
• in the inhibition of heat-induced denaturation of albumin
• as a pharmacological agent in the preparation of superfusion solution for electrophysiology studies
• to block the gap junctions
Biochem/physiol Actions: Cyclooxygenase (IC50 = 0.6 μM) and 5-lipoxygenase (IC50 = 46.3 μM) inhibitor.
Biochem/physiol Actions: Meclofenamic acid (MFA) is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug. It inhibits prostaglandin biosynthesis pathway and finds its application in the treatment of postoperative and traumatic inflammation and swelling. MFA functions in opening the potassium voltage-gated channel subfamily Q member 2/member 3 (KCNQ2/Q3).
General description: Meclofenamic acid consists of two aryl moieties that are twisted in perpendicular orientation, it includes N-2,6-dichloro-3-methylphenyl group and N-2-benzoic acid group. Because of the low aqueous solubility of the compound, it is commercially available as sodium salt.
Packaging: 1, 5 g in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥93% (HPLC)
UNSPSC 12352106

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