1-Methylhistamine dihydrochloride
SIGMA/M4910 - ≥98% (TLC), powder
Synonym: 1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
CAS Number: 6481-48-7
Empirical Formula (Hill Notation): C6H11N3 · 2HCl
Molecular Weight: 198.09
MDL Number: MFCD00037000
Linear Formula: C6H11N3 · 2HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M4910-100MG
| assay | ≥98% (TLC) |
| form | powder |
| InChI | 1S/C6H11N3.2ClH/c1-9-4-6( |
| InChI key | AGXVEALMQHTMSW-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | Cl[H].Cl[H].Cn1cnc(CCN)c1 |
| solubility | water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow |
| storage temp. | 2-8°C |
| Application: | 1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity. |
| Biochem/physiol Actions: | 1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions. |
| Biochem/physiol Actions: | Major metabolite of histamine by histamine N-methyltransferase. |
| Packaging: | 100 mg in glass bottle |
| Packaging: | 25 mg in poly bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (TLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352204 |