Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse

SIGMA/M4939 - immunodominant epitope of MOG

Synonym: MOG Peptide 35-55 Rat, Mouse

CAS Number: 163913-87-9
MDL Number: MFCD02265607
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M4939-.5MG	0.5 mg	$291.00 1/EA	Add To Favorites
45-M4939-1MG	1 mg	$488.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	cell analysis
assay	≥97% (HPLC)
color	white
form	powder
Quality Level	200
storage temp.	−20°C
UniProt accession no.	Q61885
	Q63345

Amino Acid Sequence:	Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys
Application:	Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.: This paper investigates the delayed therapeutic administration of erythropoietin and its derivatives in the treatment of autoimmune encephalomyelitis, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce the disease model in mice (Savino et al., 2006 ). Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE.: This research explores the role of serotonin reuptake in modulating immune responses and susceptibility to autoimmune diseases, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce experimental autoimmune encephalomyelitis in mice (Hofstetter et al., 2005 ). Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.: The study demonstrates the effectiveness of trichostatin A, a histone deacetylase inhibitor, in treating experimental autoimmune encephalomyelitis. Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 was used to induce the disease model in rats and mice, providing insights into potential epigenetic therapies (Camelo et al., 2005 ).
Biochem/physiol Actions:	Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
General description:	Myelin oligodendrocyte glycoprotein (MOG) is a component of the central nervous system and present on the surface of oligodendrocytes and myelin. Its extracellular domain is widely used to generate an autoimmune animal model of multiple sclerosis. In rats, it is expressed in the hippocampus.
Other Notes:	Lyophilized from 0.1% TFA in H2O

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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