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E-4031

SIGMA/M5060 - ≥98% (HPLC), lyophilized powder

Synonym: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

CAS Number: 113559-13-0
Empirical Formula (Hill Notation): C21H27N3O3S · 2HCl
Molecular Weight: 474.44
MDL Number: MFCD01754739
Linear Formula: C21H27N3O3S · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M5060-.1MG 0.1 mg
 $290.00
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45-M5060-.5MG 0.5 mg
 $838.00
1/EA		 Add To Favorites
45-M5060-1MG 1 mg
 $1470.00
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assay ≥98% (HPLC)
color white
form lyophilized powder
InChI 1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
InChI key ZQBNWMFBOSOOLX-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
solubility H2O: soluble
storage condition desiccated
storage temp. −20°C
technique(s) cell culture | embryo: suitable
Application: E-4031 has been used as:
• human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
• IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
•  IKr blocker in rat ventricular myocytes
Biochem/physiol Actions: E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.
Biochem/physiol Actions: E-4031 selectively blocks hERG K+ channels.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 0.1, 0.5, 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352207

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