Moniliformin sodium salt from Fusarium proliferatum
SIGMA/M5269
Synonym: 1-
CAS Number: 71376-34-6
Empirical Formula (Hill Notation): C4HNaO3
Molecular Weight: 120.04
MDL Number: MFCD00056566
Linear Formula: C4HO3Na
Product Type: Chemical
| InChI | 1S/C4H2O3.Na/c5-2-1-3(6)4 |
| InChI key | FERDNJVXTWPNSA-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | O=C1C(C=C1[O-])=O.[Na+] |
| storage temp. | 2-8°C |
| Application: | Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard: • to test its acute oral toxicity in mice • to test its subacute toxic effects in rats • in characterizing mycotoxins from Aspergillus |
| Biochem/physiol Actions: | Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats. It inhibits the tricarboxylic acid (TCA) cycle oxidation step. By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway. ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast. |
| General description: | Moniliformin (MON), a mycotoxin and small ionic molecule, is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum. It is present as sodium or potassium salt of semisquaric acid naturally. MON is also present in maize and small-grain cereals. |
| Packaging: | 1 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |