Matrine

SIGMA/M5319

Synonym: Matridin-15-one; Sophocarpidine

CAS Number: 519-02-8
Empirical Formula (Hill Notation): C₁₅H₂₄N₂O
Molecular Weight: 248.36
MDL Number: MFCD00210527
Linear Formula: C₁₅H₂₄N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M5319-100MG	100 mg	$402.00 1/EA	Add To Favorites
45-M5319-500MG	500 mg	$895.00 1/EA	Add To Favorites

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This image depicts SKU: M5319-100MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
InChI	1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
InChI key	ZSBXGIUJOOQZMP-JLNYLFASSA-N
Quality Level	100
SMILES string	O=C1CCCC2C3CCCN4CCCC(CN12)C34
storage temp.	2-8°C

Application:	Matrine has been used: • to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells • as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells, and ovarian cancer cells • to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells • as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines
Biochem/physiol Actions:	Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties. It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level. Matrine may also serve as an effective sedative agent. It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice. It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.
Biochem/physiol Actions:	Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.
General description:	Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.
Packaging:	100, 500 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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