PX 12

SIGMA/M5324 - ≥98% (HPLC), powder

Synonym: 2-[(1-methylpropyl)dithio]-1H-imidazole

CAS Number: 141400-58-0
Empirical Formula (Hill Notation): C₇H₁₂N₂S₂
Molecular Weight: 188.31
MDL Number: MFCD18086851
Linear Formula: C₇H₁₂N₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M5324-5MG	5 mg	$165.00 1/EA		Add To Favorites
45-M5324-25MG	25 mg	$662.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white to tan
form	powder
InChI	1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChI key	BPBPYQWMFCTCNG-UHFFFAOYSA-N
Quality Level	100
SMILES string	CCC(C)SSc1ncc[nH]1
solubility	DMSO: >25 mg/mL
storage temp.	2-8°C

Application:	PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.
Biochem/physiol Actions:	PX 12 is a thioredoxin inhibitor.
Biochem/physiol Actions:	PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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