(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide

SIGMA/M5939 - >95% (HPLC)

Synonym: GM6001; Galardin; Ilomastat

CAS Number: 142880-36-2
Empirical Formula (Hill Notation): C₂₀H₂₈N₄O₄
Molecular Weight: 388.46
Linear Formula: C₂₀H₂₈N₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M5939-5MG	5 mg	$732.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	>95% (HPLC)
form	solid
InChI	1S/C20H28N4O3/c1-12(2)15(10-18(25)21-3)19(26)24-17(20(27)22-4)9-13-11-23-16-8-6-5-7-14(13)16/h5-8,11-12,15,17,23H,9-10H2,1-4H3,(H,21,25)(H,22,27)(H,24,26)/t15-,17+/m1/s1
InChI key	PFBWZAGFLVKAGR-WBVHZDCISA-N
Quality Level	200
SMILES string	CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O
storage temp.	2-8°C

Application:	(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide has been used: • To study its effect on the profiling of active aggrecanases and their specific aggrecan degradation fragments. • To study the involvement of autocrine EGF (epidermal growth factor) receptor activation in the regulation of the morphogenetic process, using human umbilical vein endothelial cells. • To study the effect of GM6001 blockade on the expression of angiotensin II, the interstitial collagenases and soluble elastin fragments in explant culture supernatants.
Biochem/physiol Actions:	GM6001 promotes cardiovascular and hepatocellular function.
Biochem/physiol Actions:	Inhibits a wide variety of matrix metalloproteases with K_is in the nanomolar range. Active in a number of animal models of diseases where matrix metalloproteases are thought to be involved.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	>95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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