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2-Methyl-4-isothiazolin-3-one hydrochloride

SIGMA/M6045 - ≥99%

Synonym: MIT hydrochloride; Methylisothiazolinone hydrochloride

CAS Number: 26172-54-3
Empirical Formula (Hill Notation): C4H5NOS · HCl
Molecular Weight: 151.61
EC Number: 247-499-3
MDL Number: MFCD06804636
Linear Formula: C4H5NOS · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M6045-1G 1 g
 $166.00
1/EA		 Add To Favorites
45-M6045-5G 5 g
 $562.00
1/EA		 Add To Favorites

 

application(s) microbiology
assay ≥99%
biological source synthetic
color white to beige
concentration ≤ 100%
form powder
InChI 1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
InChI key SJXPQSRCFCPWQQ-UHFFFAOYSA-N
mode of action protein synthesis | interferes
mp 165—170 °C ((329 - 338 °F) at ca.990.4 hPa)
Quality Level 200 
SMILES string Cl[H].CN1SC=CC1=O
solubility water: soluble 10.0 — 10.4 mg/mL, clear, colorless to faint yellow or tan
storage temp. 2-8°C
suitability suitable for component for culture media
technique(s) cell culture | mammalian: suitable
Application: Methylisothiazolinone (MIT HCl) has been used:


• as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
• to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites
Biochem/physiol Actions: 2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT HCl is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.
General description: 2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a derivative of the synthetic isothiazolinone.
Purity ≥99%
mp 165—170 °C ((329 - 338 °F) at ca.990.4 hPa)
Storage Temp. 2-8°C
UNSPSC 51102829

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