Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit
SIGMA/M6057 - ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-MMP-12
MDL Number: MFCD03455403
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| mol wt | antigen 54 kDa |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:3,000 |
| UniProt accession no. | P39900  |
| Biochem/physiol Actions: | Matrix metalloproteinase-12 (MMP-12) is involved in breaking down proteoglycans, collagen type IV and laminin. Its main substrate is elastin. |
| Biochem/physiol Actions: | The antibody recognizes only the latent form of MMP-12 and not the active forms. May be used to distinguish the zymogen and the activated enzyme. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on human chromosome 11. |
| Immunogen: | synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-12 (macrophage elastase). |
| Physical form: | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide. |
| Safety Statements | 23.3-24/25 |
| WGK Germany | 1 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |