7-Methylguanosine 5′-triphosphate sodium salt

SIGMA/M6133 - ≥85% (HPLC)

Synonym: m7GTP

CAS Number: 104809-18-9
Empirical Formula (Hill Notation): C₁₁H₁₈N₅O₁₄P₃ · xNa⁺
Molecular Weight: 537.21 (free acid basis)
MDL Number: MFCD00063376
Linear Formula: C₁₁H₁₈N₅O₁₄P₃ · xNa⁺
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M6133-5MG	5 mg	$226.00 1/EA		Add To Favorites
45-M6133-10MG	10 mg	$370.00 1/EA		Add To Favorites
45-M6133-25MG	25 mg	$740.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (HPLC)
biological source	natural (inorganic)
form	powder
InChI	1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1
InChI key	FSMRTZAMTMQMEF-OCMBMSOASA-M
Quality Level	200
SMILES string	[Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13
solubility	water: 50 mg/mL, clear, colorless to faint yellow or tan
storage temp.	−20°C

Application:	7-Methylguanosine 5′-triphosphate (m7GTP) is use to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP may be used to create affinity media for capture and purification of molecules such as eukaryotic initiation factor eIF4E.
Application:	7-Methylguanosine 5′-triphosphate sodium salt has been used to test its affinity towards Poly(A)-specific ribonuclease (PARN) polypeptides using fluorescence titrations. It has also been used in crystallization along with gemin5 fragment (G5N) and DM15 region of human La-related 15 protein 1 ( LARP1).
Biochem/physiol Actions:	7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes. m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP has a high affinity for eukaryotic initiation factor eIF4E and may be used to create affinity media for their capture and purification.
General description:	7-Methylguanosine 5′-triphosphate is a mRNA cap structural analog.
Packaging:	5, 10, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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