GW9662

SIGMA/M6191 - >98% (HPLC)

Synonym: 2-Chloro-5-nitro-N-phenylbenzamide

CAS Number: 22978-25-2
Empirical Formula (Hill Notation): C₁₃H₉ClN₂O₃
Molecular Weight: 276.68
MDL Number: MFCD01215270
Linear Formula: C₁₃H₉ClN₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M6191-5MG	5 mg	$99.70 1/EA		Add To Favorites
45-M6191-25MG	25 mg	$399.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	>98% (HPLC)
color	white
form	powder
InChI	1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
InChI key	DNTSIBUQMRRYIU-UHFFFAOYSA-N
Quality Level	200
SMILES string	[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccccc2
solubility	DMSO: 26 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Application:	GW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.
Biochem/physiol Actions:	GW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.
Biochem/physiol Actions:	GW9662 is an irreversible PPARγ antagonist. GW9662 inhibits connective tissue growth factor and activation of CD36 by IL-4.
Biochem/physiol Actions:	GW9662 is an irreversible PPARγ antagonist; inhibits connective tissue growth factor, and activation of CD36 by IL-4.
Features and Benefits:	This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Legal Information:	Sold for research purposes only, under agreement from GlaxoSmithKline
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xi
Risk Statements	36-43
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	>98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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