MRS 1754 hydrate
SIGMA/M6316 - ≥98% (HPLC), solid
Synonym: 8-
CAS Number: 264622-58-4 (anhydrous)
Empirical Formula (Hill Notation): C26H26N6O4 · xH2O
Molecular Weight: 486.52 (anhydrous basis)
MDL Number: MFCD11046004
Linear Formula: C26H26N6O4 · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white |
| form | solid |
| InChI | 1S/C26H26N6O4.H2O/c1-3-13 |
| InChI key | ZACJDWOPQROWIK-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O.CCCN1C(=O)N(CCC)c2[nH]c |
| solubility | DMSO: soluble >10 mg/mL |
| storage temp. | room temp |
| Application: | MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist: • to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs) • blastema formation in zebrafish • to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same |
| Biochem/physiol Actions: | MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug. |
| Biochem/physiol Actions: | MRS 1754 hydrate is a potent A2B adenosine receptor antagonist. |
| Features and Benefits: | This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Legal Information: | Manufactured and sold under license from Adenosine Therapeutics LLC. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |