2-Methoxyestradiol

SIGMA/M6383 - powder

Synonym: 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether; 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether; 2-Hydroxyestradiol 2-methyl ether; 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene

CAS Number: 362-07-2
Empirical Formula (Hill Notation): C₁₉H₂₆O₃
Molecular Weight: 302.41
MDL Number: MFCD00010489
Linear Formula: C₁₉H₂₆O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M6383-5MG	5 mg	$97.20 1/EA	Add To Favorites
45-M6383-10MG	10 mg	$142.00 1/EA	Add To Favorites
45-M6383-50MG	50 mg	$508.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M6383-10MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
	≥98% (TLC)
color	white to faint yellow
form	powder
InChI	1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
InChI key	CQOQDQWUFQDJMK-SSTWWWIQSA-N
mp	189-190 °C
Quality Level	200
shipped in	ambient
SMILES string	OC1=C(C=C(C2=C1)[C@]3([H])[C@](CC2)([H])[C@]4([H])CC[C@H](O)[C@](C)4CC3)OC
solubility	DMSO: 10 mg/mL
	ethanol: 10 mg/mL
	H₂O: insoluble
sterility	non-sterile
storage temp.	room temp

Application:	2-Methoxyestradiol has been used: • as hypoxia-inducible factor 1-alpha (HIF-1α) inhibitor to treat microglia to test whether hypoxia leads to cell death • to determine the anticancer potential in L-lactate-activated osteosarcoma cells • as a reference chemical and angiogenesis inhibitor to assess the performance of in vitro angiogenesis assay
Biochem/physiol Actions:	2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis.It has little affinity for classical estrogen receptors.
Biochem/physiol Actions:	2-Methoxyestradiol plays a key role in the apoptosis of tumor cells. It also participates in microtubule stabilization. It exhibits cardioprotective activity and acts as an anticancer agent.
General description:	2-Methoxyestradiol (2-ME) is a metabolite, derived from estradiol. It is usually seen at high levels in the normal follicle.
Packaging:	5, 10, 50 mg in glass bottle

Symbol	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H301 + H311 + H331 - H315 - H319 - H335 - H350 - H360 - H372 - H410
Precautionary statements	P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
Hazard Codes	T,N
Risk Statements	45-46-60-61-23/24/25-36/37/38-48-51/53
Safety Statements	53-22-26-36/37/39-45-61
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC); ≥98% (TLC)
mp	189-190 °C
Storage Temp.	room temp
UNSPSC	51111800

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