Manumycin A from Streptomyces parvulus

SIGMA/M6418

CAS Number: 52665-74-4
Empirical Formula (Hill Notation): C₃₁H₃₈N₂O₇
Molecular Weight: 550.64
MDL Number: MFCD00920782
Linear Formula: C₃₁H₃₈N₂O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M6418-5MG	5 mg	$860.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
form	powder
InChI	1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28?,29-,31+/m1/s1
InChI key	TWWQHCKLTXDWBD-YCWSEAROSA-N
Quality Level	200
SMILES string	CCCC[C@@H](C)C=C(C)C=C(/C)C(=O)NC1=C[C@@](O)(C=CC=CC=CC(=O)NC2=C(O)CCC2=O)[C@@H]3O[C@H]3C1=O
solubility	methanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow
storage temp.	2-8°C

Application:	Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay.
Biochem/physiol Actions:	Manumycin A is a natural monomeric epoxyquinoid. It has an ability to inhibit tumor necrosis factor (TNF) induced IκB kinase (IKK) activity in various cell types. In addition, manumycin A exhibits anti-tumor property by inhibiting farnesylation of oncogenic Ras.
Biochem/physiol Actions:	Potent inhibitor of Ras farnesyltransferase.
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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