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Mitoxantrone dihydrochloride

SIGMA/M6545 - ≥97% (HPLC)

Synonym: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

CAS Number: 70476-82-3
Empirical Formula (Hill Notation): C22H28N4O6 · 2HCl
Molecular Weight: 517.40
EC Number: 274-619-1
MDL Number: MFCD00242943
Linear Formula: C22H28N4O6 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M6545-10MG 10 mg
 $73.30
1/EA		 Add To Favorites
45-M6545-50MG 50 mg
 $255.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M6545-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M6545-50MG

 

assay ≥97% (HPLC)
InChI 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChI key ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
Application: Mitoxantrone dihydrochloride has been used:
• to induce calreticulin surface expression in cells
• as a genotoxin agent
• as a topoisomerase inhibitor
Biochem/physiol Actions: Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.
Packaging: 10, 50 mg in glass bottle
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H340 - H360
Precautionary statements P201 - P308 + P313
Hazard Codes T
Risk Statements 46-61
Safety Statements 53-36/37/39-45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
UNSPSC 12352005

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