[Met⁵]Enkephalin acetate salt hydrate

SIGMA/M6638 - ≥95.0% (HPLC), powder

Synonym: Enkephalin M; [5-Methionine]Enkephalin

CAS Number: 82362-17-2
Empirical Formula (Hill Notation): C₂₇H₃₅N₅O₇S · xC₂H₄O₂ · yH₂O
Molecular Weight: 573.66 (anhydrous free base basis)
MDL Number: MFCD03788202
Linear Formula: C₂₇H₃₅N₅O₇S · xC₂H₄O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M6638-1MG	1 mg	$38.30 1/EA	Add To Favorites
45-M6638-5MG	5 mg	$78.10 1/EA	Add To Favorites
45-M6638-10MG	10 mg	$128.00 1/EA	Add To Favorites
45-M6638-25MG	25 mg	$227.00 1/EA	Add To Favorites
45-M6638-100MG	100 mg	$773.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M6638-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95.0% (HPLC)
color	white
composition	acetate, 2.5-20%
form	powder
InChI	1S/C27H35N5O7S.C2H4O2.H2O/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18;1-2(3)4;/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39);1H3,(H,3,4);1H2/t20-,21-,22-;;/m0../s1
InChI key	NNACMJQGYXGHNE-DUQFDOSRSA-N
Quality Level	200
SMILES string	O=C([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@@H](N)CC(C=C2)=CC=C2O)=O)=O)=O)N[C@@H](CCSC)C(O)=O.CC(O)=O.[H]O[H]
storage temp.	−20°C

Amino Acid Sequence:	Tyr-Gly-Gly-Phe-Met
Application:	[Met5] Enkephalin acetate salt hydrate has been used to study the effect of mutations in opioid growth factor receptor on growth of human cancer cell line.
Biochem/physiol Actions:	Met-enkephalin is endogenous opioid neurotransmitter/neuromodulator with agonist activity at μ and δ opioid receptors. Enhancement of immune system function is mediated through met-enkephalin receptors on leukocytes. Met-enkephalin also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors.
Biochem/physiol Actions:	Opioid peptides play a crucial role in various physiological process such as pain mediation, opiate dependence and euphoria and members of this class contain aromatic residues in positions 1 and 4. [Met5] Enkephalin acts as a cytokine and is implicated in improving immune response in patients with cancer or AIDS. [Met5] Enkephalin boosts immune functions at low concentration and suppress at high concentration. ME is associated with glucose homeostasis. Increased concentration of ME is observed in plasma of type I diabetic patients.
General description:	[Met5] Enkephalin (ME) is an opioid pentapeptide, which acts as a neurotransmitter or neuromodulator in the central nervous system. [Met5] Enkephalin is activated on interaction with three main subtypes of receptors including μand δ opioid receptors mediating classic opioid effects of met-Enk and ζ -receptors mediating non-opioid actions of the peptide, i.e. retardation of cell growth. [Met5] Enkephalin is derived from precursor peptide pro-methionine-enkephalin in vitro consisting of H-Tyr-Gly-Gly-Phe-Met-Arg-OH amino acid sequence. The peptide activity is observed in the central nervous, neuroendocrine and immune systems.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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