MDL 28170
SIGMA/M6690 - ≥90% (TLC)
Synonym: Calpain Inhibitor III
CAS Number: 88191-84-8
Empirical Formula (Hill Notation): C22H26N2O4
Molecular Weight: 382.45
MDL Number: MFCD00798796
Linear Formula: C22H26N2O4
Product Type: Chemical
| assay | ≥90% (TLC) |
| composition | Peptide Content, >90% |
| InChI | 1S/C22H26N2O4/c1-16(2)20( |
| InChI key | NGBKFLTYGSREKK-ANYOKISRSA |
| Quality Level | 200  |
| shipped in | wet ice |
| SMILES string | [H]C(=O)C(Cc1ccccc1)NC(=O |
| solubility | DMSO: 26 mg/mL |
| H2O: insoluble | |
| methanol: soluble | |
| storage temp. | 2-8°C |
| Amino Acid Sequence: | Z-Val-Phe-al |
| Application: | MDL 28170 has been used as a calpain inhibitor: • to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest • to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle • to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain |
| Biochem/physiol Actions: | MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes. |
| Biochem/physiol Actions: | MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor. |
| Biochem/physiol Actions: | Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (TLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |