Mithramycin A from Streptomyces plicatus

SIGMA/M6891 - ≥90% (HPLC)

Synonym: Aureolic acid; Plicamycin

CAS Number: 18378-89-7
Empirical Formula (Hill Notation): C₅₂H₇₆O₂₄
Molecular Weight: 1085.15
MDL Number: MFCD00135618
Linear Formula: C₅₂H₇₆O₂₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M6891-1MG	1 mg	$225.00 1/EA		Add To Favorites
45-M6891-5MG	5 mg	$943.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	≥90% (HPLC)
InChI	1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43+,44-,45-,49+,50+,51-,52+/m1/s1
InChI key	CFCUWKMKBJTWLW-BGLFSJPPSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
SMILES string	[H][C@]1(Cc2cc3cc(O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@@H](O)[C@@H](C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1O[C@H]6C[C@@H](O[C@H]7C[C@@H](O[C@H]8C[C@](C)(O)[C@H](O)[C@@H](C)O8)[C@H](O)[C@@H](C)O7)[C@H](O)[C@@H](C)O6)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O
storage temp.	2-8°C

Biochem/physiol Actions:	Anticancer antibiotic.
Biochem/physiol Actions:	Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Chemical structure: aureolic acid
Packaging:	1, 5 mg in serum bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12161501

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