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MPP dihydrochloride hydrate

SIGMA/M7068 - ≥97% (HPLC), white, powder

Synonym: 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate; Methyl-piperidino-pyrazole hydrate

CAS Number: 911295-24-4 (anhydrous)
Empirical Formula (Hill Notation): C29H31N3O3 · 2 HCl · xH2O
Molecular Weight: 542.50 (anhydrous basis)
MDL Number: MFCD06411603
Linear Formula: C29H31N3O3 · 2 HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M7068-10MG 10 mg
 $228.00
1/EA		 Add To Favorites
45-M7068-25MG 25 mg
 $477.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white
form powder
InChI 1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H
InChI key FWDNPWVVRVSJQH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5
solubility DMSO: soluble ≥20 mg/mL
storage condition desiccated
Application: MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:
• in human breast cancer MCF-7 cells
• to pre-treat endometrial ex vivo organ cultures (EVOCs)
• to treat pituitary glands to monitor luteinizing hormone secretion
Biochem/physiol Actions: Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β. It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.
Biochem/physiol Actions: MPP dihydrochloride is a specific estrogen receptor α antagonist.
Biochem/physiol Actions: Specific estrogen receptor α antagonist.
General description: Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Packaging: 10, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
UNSPSC 51111800

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