Monoamine Oxidase B human
SIGMA/M7441 - recombinant, expressed in baculovirus infected BTI insect cells
Synonym: MAO-B
MDL Number: MFCD04040933
Product Type: Chemical
Monoamine oxidases are a group of enzymes that catalyze the oxidative deamination of primary monoamines.
| enzyme activity | ≥1 U/mg |
| form | liquid |
| packaging | vial of ~2.5 mg |
| Quality Level | 100  |
| recombinant | expressed in baculovirus infected BTI insect cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P27338  |
| Application: | Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. |
| Application: | Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain. |
| Biochem/physiol Actions: | MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme. |
| General description: | Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs. |
| Other Notes: | kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | enzyme activity: ≥1 U/mg |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 1.4.3.4 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |