Methotrexate

SIGMA/M7824

Synonym: Methotrexate; (+)-Amethopterin; 4-Amino-10-methylfolic acid; 4-Amino-N¹⁰-methylpteroyl-L-glutamic acid; Antifolan; MTX; Methylaminopterin

CAS Number: 59-05-2
Empirical Formula (Hill Notation): C₂₀H₂₂N₈O₅
Molecular Weight: 454.44
EC Number: 200-413-8
MDL Number: MFCD00064370
Linear Formula: C₂₀H₂₂N₈O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M7824-1G	1 g	$2840.00 1/EA	Add To Favorites
45-M7824-5G	5 g	$12270.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

biological source	synthetic
form	powder
InChI	1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChI key	FBOZXECLQNJBKD-ZDUSSCGKSA-N
Quality Level	400
SMILES string	CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
storage temp.	−20°C
suitability	suitable for manufacturing use

General description:	Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.
General description:	Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program. M-Clarity Program Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
Legal Information:	SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Packaging:	1, 5 g in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H315 - H319 - H341 - H360D
Precautionary statements	P201 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	46-61-25-36/38
Safety Statements	53-26-36-45
RIDADR	UN 1544PSN1 6.1 / PGIII
WGK Germany	WGK 3

Storage Temp.	−20°C
UNSPSC	41116107

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