Mifepristone

SIGMA/M8046 - ≥98%

Synonym: 11β-(4-Dimethylamino)phenyl-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; RU-38486; RU-486

CAS Number: 84371-65-3
Empirical Formula (Hill Notation): C₂₉H₃₅NO₂
Molecular Weight: 429.59
MDL Number: MFCD00867226
Linear Formula: C₂₉H₃₅NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M8046-100MG	100 mg	$103.00 1/EA	Add To Favorites
45-M8046-500MG	500 mg	$387.00 1/EA	Add To Favorites
45-M8046-1G	1 g	$663.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M8046-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
biological source	synthetic (organic)
form	powder
InChI	1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChI key	VKHAHZOOUSRJNA-GCNJZUOMSA-N
originator	Danco Laboratories
shipped in	ambient
SMILES string	[H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C
solubility	ethanol: 50 mg/mL, clear, greenish-yellow
sterility	non-sterile
storage temp.	2-8°C
technique(s)	inhibition assay: suitable

Application:	Mifepristone has been used: • to induce damage against the proliferative and secretory phase of endometrial stromal cells • to establish a preterm birth (PTB) mice model in order to study the difference in cervical ripening mechanism between term and PTBs • to activate geneswitch gal4 in flies • to study the effects of sex steroids on prostaglandin secretion
Biochem/physiol Actions:	Mifepristone (RU-486) has activity as both a progesterone receptor antagonist and a glucocorticoid receptor antagonist.
Biochem/physiol Actions:	Therefore, mifepristone is considered to be a potent abortifacient. It is also known to inhibit human chorionic gonadotropin. Mifepristone results in decidual necrosis.
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Danco Laboratories . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Mifepristone, a synthetic steroid, can be utilized for the management of Cushing′s syndrome and uterine leiomyomas. At low doses, it selectively antagonizes progesterone by binding to the intracellular progesterone receptor. At higher doses, mifepristone blocks cortisol at the glucocorticoid receptor, affecting the hypothalamic-pituitary-adrenal axis and leading to increased circulating cortisol, thereby controlling hyperglycemia in some patients. Additionally, mifepristone has a higher affinity for the glucocorticoid II receptor than for the glucocorticoid I receptor. In cases of pregnancy termination, mifepristone disrupts progesterone.
Packaging:	1 g in glass bottle
Packaging:	100, 500 mg in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201 - P308 + P313
Hazard Codes	T
Risk Statements	60-61
Safety Statements	53-22-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	51111800

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