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α-Methyl-DL-tryptophan

SIGMA/M8377 - crystalline

Synonym: α-methyl-tryptophan

CAS Number: 153-91-3
Empirical Formula (Hill Notation): C12H14N2O2
Molecular Weight: 218.25
MDL Number: MFCD00038416
Linear Formula: C12H14N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M8377-100MG 100 mg
 $88.20
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45-M8377-250MG 250 mg
 $142.00
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45-M8377-1G 1 g
 $425.00
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assay ≥98% (TLC)
color light yellow
form crystalline
InChI 1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)
InChI key ZTTWHZHBPDYSQB-UHFFFAOYSA-N
Quality Level 200 
SMILES string CC(N)(Cc1c[nH]c2ccccc12)C(O)=O
storage temp. 2-8°C
technique(s) tissue culture: suitable
Application:

  • Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis.: This study explores the use of a-Methyl-DL-tryptophan in enhancing sonodynamic tumor therapy through the deprivation of glutamine and inducing thrombosis, offering a new approach to cancer treatment (Zhou et al., 2023 ).

  • Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery.: This article describes the application of a-Methyl-DL-tryptophan in developing transporter-targeted prodrugs, enhancing drug delivery systems, particularly in ocular treatments (Vooturi et al., 2012 ).

  • SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer.: The study investigates the role of a-Methyl-DL-tryptophan in targeting SLC6A14 for treating estrogen receptor-positive breast cancer, highlighting its potential as a therapeutic agent (Karunakaran et al., 2011 ).
Biochem/physiol Actions: α-methyl-DL-tryptophan is a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
Storage Temp. 2-8°C
UNSPSC 12352209

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