Monastrol
SIGMA/M8515 - ≥98% (HPLC), solid
Synonym: 4-
CAS Number: 254753-54-3
Empirical Formula (Hill Notation): C14H16N2O3S
Molecular Weight: 292.35
MDL Number: MFCD00813077
Linear Formula: C14H16N2O3S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C14H16N2O3S/c1-3-19-13 |
| InChI key | LOBCDGHHHHGHFA-UHFFFAOYSA |
| mp | 185-185.9 °C (lit.) |
| Quality Level | 100  |
| SMILES string | CCOC(=O)C1=C(C)NC(=S)NC1c |
| solubility | DMSO: >5 mg/mL |
| storage condition | protect from light |
| storage temp. | 2-8°C |
| Application: | Monastrol has been used: • to treat MDA-MB-231 cells as a non-microtubule-targeting agent • as a antineoplastic agent, to treat mouse myeloma cell line SP 2/0, to induce apoptosis and to elucidate the role of metabotropic glutamate receptor 3 (Grm3) in apoptosis • as an inhibitor of pteridine reductase in GFP-transfected promastigotes infected macrophages for flow cytometer-based growth inhibition assay and to evaluate anti-leishmanial activity of Leishmania donovani hamster model in vivo |
| Biochem/physiol Actions: | Monastrol is a potent, cell-permeant inhibitor of mitosis. Monastrol arrested cells are characterized by monopolar spindles. This phenotype is induced through specific disruption of mitotic molecular motor kinesin Eg5 with IC50 at 14 μM. No effect on other motor proteins and tubulin. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 1, 5 mg in glass bottle |
| Packaging: | Packaged under inert gas. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 185-185.9 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |