Methyl-3,4-dephostatin

SIGMA/M9440 - >98% (HPLC), powder

Synonym: 3,4-Dihydroxy-N-methyl-N-nitrosoaniline

CAS Number: 173043-84-0
Empirical Formula (Hill Notation): C₇H₈N₂O₃
Molecular Weight: 168.15
MDL Number: MFCD01076450
Linear Formula: C₇H₈N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M9440-1MG	1 mg	$222.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	>98% (HPLC)
color	red-brown
form	powder
InChI	1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3
InChI key	XAKAQCMEMMZUEO-UHFFFAOYSA-N
Quality Level	100
SMILES string	CN(N=O)c1ccc(O)c(O)c1
solubility	DMSO: soluble 18 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Application:	Methyl-3,4-dephostatin has been used as: • an inhibitor for methyltransferases • a kinase-related inhibitor for human transglutaminase • a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein
Biochem/physiol Actions:	Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).
Biochem/physiol Actions:	Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	>98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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