Mirin
SIGMA/M9948 - ≥98% (HPLC), powder
Synonym: 5-
CAS Number: 299953-00-7
Empirical Formula (Hill Notation): C10H8N2O2S
Molecular Weight: 220.25
MDL Number: MFCD05885480
Linear Formula: C10H8N2O2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | red to orange |
| form | powder |
| InChI | 1S/C10H8N2O2S/c11-10-12-9 |
| InChI key | YBHQCJILTOVLHD-YVMONPNESA |
| Quality Level | 100  |
| SMILES string | NC1=NC(=O)C(S1)=Cc2ccc( |
| solubility | DMSO: >10 mg/mL |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Mirin has been used: • as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation • as Mre11 inhibitior in BSC-1 cells infected with simian virus 40 • in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25) |
| Biochem/physiol Actions: | Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP. |
| Biochem/physiol Actions: | Mirin is an inhibitor of the Mre11–Rad50–Nbs1 complex. |
| Biochem/physiol Actions: | Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |