Arginase Activity Assay Kit
SIGMA/MAK112 - sufficient for 200 colorimetric tests
Synonym: Arginase Test Kit
Product Type: Chemical
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| detection method | colorimetric |
| relevant disease(s) | cancer; immunological diseases; gastrointestinal diseases |
| storage temp. | −20°C |
| usage | sufficient for 200 colorimetric tests |
| Application: | Arginase Activity Assay Kit has been used to assess the activity of arginase. |
| Application: | Suitable for the detection of arginase activity in enzyme preparations, serum, plasma, tissue culture, and similar samples. Suitable for studying the effects of drugs on arginase activity. |
| Biochem/physiol Actions: | In this assay, arginase catalyzes the conversion of arginine to urea and ornithine. The urea produced specifically reacts with the substrate to generate a colored product, proportional to the arginase activity present. |
| Features and Benefits: | Compatible with high-throughput handling systems. |
| General description: | Arginase is a manganese-containing enzyme that catalyzes the conversion of arginine to urea and ornithine. Two isoforms of arginase are present in most mammals which differ in their tissue distribution and subcellular localization. Arginase I is a cytoplasmic protein predominantly expressed in the liver where it catalyzes the fifth and final step of the Urea Cycle. Arginase II is a mitochondrial protein with broader tissue distribution whose function may include nitric oxide and polyamine metabolism. Decreased activity or expression of Arginase I results in the autosomal recessive disorder hyperarginemia. Increased serum Arginase activity is implicated in hepatic injury and in certain pathological conditions such as cancer. Arginase also participates in multiple inflammatory reactions in the immune system, such as macrophage-mediated cytotoxicity. |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H290 - H314 - H412 |
| Precautionary statements | P234 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T,N |
| Risk Statements | 60-61-22-35-43-50 |
| Safety Statements | 53-26-36/37/39-45-61 |
| RIDADR | UN 3316 9 |
| Storage Temp. | −20°C |
| UNSPSC | 12161503 |