TCA Cycle Metabolite Library

SIGMA/ML0010

Synonym: Kreb′s Cycle Metabolite Library

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-ML0010-1KT	1 kit	$887.00 1/EA	Add To Favorites

Most of the anabolic pathways start and the catabolic pathways end in the “backbone” of metabolism — Glycolysis and the TCA Cycle. This map shows some of the many pathways which cluster around pyruvate, acetyl-CoA and the TCA Cycle.

Properties
Descriptions
Safety Info.
Basic Data

Quality Level	200
storage temp.	−20°C

Application:	Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach.: This study utilizes an advanced metabolomics approach to understand mitochondrial dysfunction in long COVID patients, highlighting the application of the TCA Cycle Metabolite Library for in-depth biological analysis (Martinez et al., 2024 ). OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma.: This research explores the critical interactions in metabolic pathways, particularly the TCA cycle, affecting glioblastoma′s cellular metabolism and identifying potential therapeutic targets (Nguyen et al., 2024 ). The interactions and biological pathways among metabolomics products of patients with coronary heart disease.: Demonstrates how metabolomics, including TCA cycle metabolites, can reveal complex biochemical pathways in coronary heart disease, offering insights into potential interventions (Chu et al., 2024 ). Reduction in creatine metabolites in macrophages exposed to small molecule analogues of the anti-inflammatory parasitic worm product ES-62.: Investigates the impact of altered TCA cycle metabolites on macrophage biochemistry, providing a foundation for therapeutic research (Alanazi et al., 2024 ). In-vivo tracking of deuterium metabolism in mouse organs using LC-MS/MS.: This study applies cutting-edge analytical techniques to trace metabolic pathways in vivo, including key TCA cycle intermediates, which could be pivotal for clinical metabolic research (Kasarla et al., 2024 ).
Other Notes:	Contains 10 mg each of TCA cycle metabolite standards packaged individually.
Preparation Note:	All components are directly water soluble at ≥ 50 mg/ml.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H317 - H319 - H335
Precautionary statements	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	UN 3316 9
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	41116107
Components	Acetyl coenzyme A trisodium salt, ≥93% (HPLC), powder 10 mg; Citric acid monohydrate, reagent grade, ≥98% (GC/titration) 10 mg; Sodium fumarate dibasic, ≥99% 10 mg; L-(−)-Malic acid, ≥95% (titration) 10 mg; Oxaloacetic acid, ≥97% (HPLC) 10 mg; Sodium pyruvate, ReagentPlus^®, ≥99% 10 mg; Succinyl coenzyme A sodium salt, ≥85% 10 mg; Sodium succinate dibasic hexahydrate, ReagentPlus^®, ≥99% 10 mg; α-Ketoglutaric acid disodium salt hydrate, ≥95% 10 mg

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