SILu™Lite IL8, Interleukin-8 human
SIGMA/MSST0058 - recombinant, expressed in HEK 293 cells, MS Protein Standard
Synonym: C-X-C motif chemokine 8; Chemokine (C-X-C motif); Emoctakin; Granulocyte chemotactic protein 1 (GCP-1); IL-8; Monocyte-derived neutrophil; Monocyte-derived neutrophil-
Product Type: Chemical
SILuProt products are stable isotope-labeled full length proteins designed to be used as mass spectrometry internal standards for quantitative proteomics. Introduction of an internal SILuProt standard at the beginning of the MS workflow minimizes variations in quantification due to protein extraction, fractionation, enrichment, proteolysis and analysis
| assay | ≥95% (SDS-PAGE) |
| form | lyophilized powder |
| Quality Level | 200  |
| recombinant | expressed in HEK 293 cells |
| shipped in | ambient |
| storage temp. | −20°C |
| suitability | suitable for mass spectrometry (internal calibrator) |
| UniProt accession no. | P10145  |
| Biochem/physiol Actions: | Interleukin-8 (IL-8) is a member of the CXC chemokine subfamily and is produced by blood cells and many types of tissues. The measurement of IL-8 in voided urinary samples may have utility for urine-based detection of bladder cancer. Urinary IL-8 was a strong biomarker of stress under intensive and prolonged demands, both acutely and over time. IL-8 and cathepsin B levels were significantly elevated in melanoma patients, and more importantly, the combination of IL-8 and cathepsin B were also studied as a prognosis marker for melanoma mortality. |
| General description: | SILu™Lite IL8 is a recombinant human protein expressed in human 293 cells. It is a mixture of the 3 main CXCL8 isoforms with the molecular weights, amino acid number and relative abundance as described in Table 1 of the product datasheet. SILu™Lite IL8 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications. |
| Legal Information: | SILu is a trademark of Sigma-Aldrich Co. LLC |
| Other Notes: | EGAVLPRSAKELRCQCIKTYSKPFH |
| Physical form: | Supplied as a lyophilized powder containing phosphate buffered saline. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 23201100 |