Synonym: 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile; 3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
CAS Number: 337349-54-9
Empirical Formula (Hill Notation): C19H17N3O2S2
Molecular Weight: 383.49
MDL Number: MFCD01448275
Linear Formula: C19H17N3O2S2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| form |
solid |
| InChI |
1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3 |
| InChI key |
VGONMECBFMCKBS-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
COc1ccc(cc1)N2C(=O)c3c4CCCCc4sc3N=C2SCC#N |
| solubility |
DMSO: >10 mg/mL |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. |
| Biochem/physiol Actions: |
Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H319 - H413 |
| Precautionary statements |
P273 - P305 + P351 + P338 |
| Hazard Codes |
Xi |
| Risk Statements |
36 |
| Safety Statements |
26 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
