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Nafamostat mesylate

SIGMA/N0289 - ≥98% (HPLC)

Synonym: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate; FUT-175

CAS Number: 82956-11-4
Empirical Formula (Hill Notation): C19H17N5O2 · 2CH4O3S
Molecular Weight: 539.58
MDL Number: MFCD00941430
Linear Formula: C19H17N5O2 · 2CH4O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N0289-10MG 10 mg
 $171.00
1/EA		 Add To Favorites
45-N0289-50MG 50 mg
 $676.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
InChI key SRXKIZXIRHMPFW-UHFFFAOYSA-N
Quality Level 100 
SMILES string CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc3cc(ccc3c2)C(N)=N
solubility DMSO: 10 mg/mL, clear
  H2O: >10 mg/mL
storage temp. room temp
Application: Nafamostat mesylate has been used:
• as a serine protease inhibitor to study its effects on proteolytic degradation of therapeutic proteins recombinantly expressed in Chinese hamster ovary (CHO)-K1-derived cells
• to stop complement activation to validate the assay for murine C3 fragments
• as a serine protease inhibitor to study its effects on house dust mite extract evoked Ca2+ entry
Biochem/physiol Actions: Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation.
Biochem/physiol Actions: Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
Biochem/physiol Actions: Nafamostat mesylate is used in the treatment of disseminated intravascular coagulation (DIC), pancreatitis, and systemic inflammatory response syndrome. It can block the proliferation, adhesion, and invasion of cancer cells and repress tumor progression in animal models. Nafamostat mesylate is involved in the development of immune activity. In combination with favipiravir, nafamostat mesylate may block virus entry and replication, and inhibit the pathogenic host response. This combination treatment might be effective for critically ill Covid-19 patients.
Packaging: 10, 50 mg in glass bottle
Hazard Codes Xn
Risk Statements 63-62
Safety Statements 36/37
RIDADR NONH for all modes of transport
WGK Germany nwg
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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