Nitazoxanide

SIGMA/N0290 - ≥98% (HPLC)

Synonym: NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide

CAS Number: 55981-09-4
Empirical Formula (Hill Notation): C₁₂H₉N₃O₅S
Molecular Weight: 307.28
EC Number: 259-931-8
MDL Number: MFCD00416599
Linear Formula: C₁₂H₉N₃O₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N0290-10MG	10 mg	$92.70 1/EA		Add To Favorites
45-N0290-50MG	50 mg	$335.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	powder
InChI	1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
InChI key	YQNQNVDNTFHQSW-UHFFFAOYSA-N
originator	Romark
Quality Level	100
SMILES string	CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
storage temp.	2-8°C

Application:	Nitazoxanide has been used: • to test its anti-viral activity against chikungunya virus • as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines • to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells
Biochem/physiol Actions:	Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria. It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies. NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV). It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.
Biochem/physiol Actions:	Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria.
Biochem/physiol Actions:	Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.
Features and Benefits:	This compound was developed by Romark . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Nitazoxanide (NTZ), a thiazolide compound is a antiparasitic drug with structure similar to niclosamide.
Packaging:	10, 50 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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