Niflumic acid

SIGMA/N0630

Synonym: 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid

CAS Number: 4394-00-7
Empirical Formula (Hill Notation): C₁₃H₉F₃N₂O₂
Molecular Weight: 282.22
EC Number: 224-516-2
MDL Number: MFCD00010569
Linear Formula: C₁₃H₉F₃N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N0630-10G	10 g	$78.80 1/EA	Add To Favorites
45-N0630-25G	25 g	$176.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
InChI key	JZFPYUNJRRFVQU-UHFFFAOYSA-N
mp	203-204 °C
Quality Level	100
SMILES string	O=C(O)C1=CC=CN=C1NC2=CC(C(F)(F)F)=CC=C2
solubility	acetone: 50 mg/mL, clear to slightly hazy, yellow

Application:	Niflumic acid has been used: • as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements, to test its analgesic effect on rat dorsal root ganglion neurons post γ-aminobutyric acid induction • as a calcium-activated chloride channel (CaCC) inhibitor in C2C12 myoblasts and also to test its effect on volume-regulated anion channel (VRAC) • as an inhibitor of voltage-dependent potassium channel in human embryonic kidney (HEK 293) phoenix cells
Biochem/physiol Actions:	Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.
Biochem/physiol Actions:	Selective cyclooxygenase-2 (COX-2) inhibitor.
Features and Benefits:	This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 - H413
Precautionary statements	P264 - P270 - P273 - P301 + P310 - P405 - P501
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3

Purity	≥98% (HPLC)
mp	203-204 °C
UNSPSC	12352106

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