Nicotinamide
SIGMA/N0636 - BioReagent, suitable for cell culture, suitable for insect cell culture
Synonym: Niacinamide; Nicotinic acid amide; Pyridine-
CAS Number: 98-92-0
Empirical Formula (Hill Notation): C6H6N2O
Molecular Weight: 122.12
EC Number: 202-713-4
MDL Number: MFCD00006395
Linear Formula: C6H6N2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N0636-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N0636-500G
| assay | ≥98% (HPLC) |
| biological source | synthetic (organic) |
| color | white |
| form | powder |
| InChI | 1S/C6H6N2O/c7-6(9)5-2-1-3 |
| InChI key | DFPAKSUCGFBDDF-UHFFFAOYSA |
| mol wt | Mw 122.12 g/mol |
| mp | 128-131 °C (lit.) |
| product line | BioReagent |
| Quality Level | 200  |
| SMILES string | NC(=O)c1cccnc1 |
| solubility | water: soluble 50 mg/mL, clear, colorless |
| technique(s) | cell culture | insect: suitable |
| cell culture | mammalian: suitable |
| Application: | Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction. |
| Biochem/physiol Actions: | Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor |
| General description: | Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases. |
| Packaging: | 100, 500 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 302.0 °F - closed cup |
| Flash Point(C) | 150 °C - closed cup |
| Purity | ≥98% (HPLC) |
| mp | 128-131 °C (lit.) |
| UNSPSC | 12352205 |