NS1643

SIGMA/N0663 - ≥98% (HPLC), solid

CAS Number: 448895-37-2
Empirical Formula (Hill Notation): C₁₅H₁₀F₆N₂O₃
Molecular Weight: 380.24
MDL Number: MFCD08705418
Linear Formula: C₁₅H₁₀F₆N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N0663-5MG	5 mg	$277.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	solid
InChI	1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
InChI key	NJFVQMRYJZHGME-UHFFFAOYSA-N
Quality Level	100
SMILES string	Oc1ccc(cc1NC(=O)Nc2cc(ccc2O)C(F)(F)F)C(F)(F)F
solubility	DMSO: ≥20 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	NS1643 is ether-a-go-go (ERG) channel activator with EC₅₀ = 10.5 μM in Xenopus oocytes and hERG channels expressed in HEK293 cells.
Biochem/physiol Actions:	The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC₅₀ value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 - H319
Precautionary statements	P301 + P310 + P330 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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