NSC43067
SIGMA/N0915 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 26903-26-4
Empirical Formula (Hill Notation): C14H12OS
Molecular Weight: 228.31
MDL Number: MFCD00489751
Linear Formula: C14H12OS
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | light yellow to light tan |
| form | powder |
| InChI | 1S/C14H12OS/c1-11-7-10-14 |
| InChI key | AOUMOFQEBZGSPD-CMDGGOBGSA |
| Quality Level | 100  |
| SMILES string | Cc1ccc(s1)C(=O)C=Cc2ccc |
| solubility | DMSO: >20 mg/mL |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. |
| Biochem/physiol Actions: | NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible. |
| Features and Benefits: | This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H413 |
| Precautionary statements | P264 - P270 - P273 - P301 + P312 - P501 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |