Narasin from Streptomyces auriofaciens

SIGMA/N1271 - ≥98% (HPLC)

Synonym: 4-methylsalinomycin; Monteban; narasin A

CAS Number: 55134-13-9
Empirical Formula (Hill Notation): C₄₃H₇₂O₁₁
Molecular Weight: 765.03
MDL Number: MFCD00133653
Linear Formula: C₄₃H₇₂O₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N1271-5MG	5 mg	$208.00 1/EA		Add To Favorites
45-N1271-25MG	25 mg	$1010.00 1/EA		Add To Favorites
45-N1271-50MG	50 mg	$1910.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-positive bacteria
	viruses
assay	≥98% (HPLC)
form	powder
InChI	1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)
InChI key	VHKXXVVRRDYCIK-UHFFFAOYSA-N
mode of action	cell membrane \| interferes
Quality Level	200
SMILES string	CCC(C1OC(C(C)CC1C)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O
solubility	methanol: soluble 20 mg/mL
storage temp.	−20°C

Application:	Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.
Biochem/physiol Actions:	Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na⁺, K⁺, and H⁺ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H⁺ concentration on the inside of the Gram-positive cell. Therefore, the H⁺ ATPase pump is activated to transport out excess H⁺. The cell is depleted of its energy resources and reduces fermentative functions and cell division .
Packaging:	5, 25, 50 mg in serum bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P301 + P310
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51102829

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.