Nimodipine

SIGMA/N149

Synonym: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

CAS Number: 66085-59-4
Empirical Formula (Hill Notation): C₂₁H₂₆N₂O₇
Molecular Weight: 418.44
EC Number: 266-127-0
MDL Number: MFCD00153848
Linear Formula: C₂₁H₂₆N₂O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N149-100MG	100 mg	$116.00 1/EA	Add To Favorites
45-N149-500MG	500 mg	$476.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N149-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white to yellow
form	powder
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
originator	Bayer
Quality Level	200
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble
	H₂O: insoluble
	methanol: 62.5 mg/mL

Application:	Nimodipine has been used: • as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections • as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC) • in the pharmacological studies for the measurement of spine voltage escape
Biochem/physiol Actions:	Nimodipine enhances the survival of dopaminergic substantia nigra neurons.
Biochem/physiol Actions:	Nimodipine is a potent L-type Ca²⁺ channel antagonist.
Disclaimer:	Photosensitive
Features and Benefits:	This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	100, 500 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 - P501
Hazard Codes	Xn
Risk Statements	48/22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
UNSPSC	12352200

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