NU7026

SIGMA/N1537 - ≥98% (HPLC), solid

Synonym: 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

CAS Number: 154447-35-5
Empirical Formula (Hill Notation): C₁₇H₁₅NO₃
Molecular Weight: 281.31
MDL Number: MFCD06798345
Linear Formula: C₁₇H₁₅NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N1537-5MG	5 mg	$308.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	tan
form	solid
InChI	1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
InChI key	KKTZALUTXUZPSN-UHFFFAOYSA-N
Quality Level	100
shipped in	wet ice
SMILES string	O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
solubility	DMSO: soluble 3 mg/mL at 60 °C
	H₂O: insoluble
storage temp.	2-8°C

Application:	NU7026 has been used: • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG) • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
Application:	Potent, ATP-competitive. IC₅₀ = 0.23 μM. Selectivity over other PI3K-related kinases (IC₅₀ = 13 μM for PI3K and >100 μM for ATM and ATR).
Biochem/physiol Actions:	Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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