Novobiocin sodium salt
SIGMA/N1628 - ≥90% (HPLC)
Synonym: Albamycin; Albamycin Sodium; Cathomycin sodium
CAS Number: 1476-53-5
Empirical Formula (Hill Notation): C31H35N2NaO11
Molecular Weight: 634.61
EC Number: 216-023-6
Linear Formula: C31H35N2NaO11
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N1628-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N1628-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N1628-1G
| antibiotic activity spectrum | Gram-positive bacteria |
| assay | ≥90% (HPLC) |
| biological source | ( |
| color | white to yellow |
| form | powder |
| InChI | 1S/C31H35N2O11.Na/c1-14(2 |
| InChI key | AXOUUAINTJNFRS-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| enzyme | inhibits | |
| Quality Level | 200  |
| SMILES string | [Na+].CO[C@@H]1[C@@H](OC( |
| storage condition | ( |
| storage temp. | 2-8°C |
| Application: | For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase. |
| Application: | Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used: • in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA • in the research on the efficacy of probiotics • in the research on the efficacy of human monocytes and dendritic cells for T-cell replication |
| Biochem/physiol Actions: | Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Antimicrobial spectrum: Gram-positive bacterial. |
| Biochem/physiol Actions: | Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB. |
| Features and Benefits: | High quality antibiotic suitable for mulitple research applications |
| General description: | Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Packaging: | 1, 5, 25, 100 g in glass bottle |
| Preparation Note: | Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H317 - H319 |
| Precautionary statements | P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36-43 |
| Safety Statements | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51286504 |