Nystatin Suspension

SIGMA/N1638 - suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture

Synonym: Fungicidin; Mycostatin

CAS Number: 1400-61-9
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N1638-20ML	20 mL	$26.30 1/EA		Add To Favorites
45-N1638-100ML	100 mL	$68.60 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	yeast
color	yellow
concentration	10,000 unit/mL in DPBS
form	suspension
impurities	endotoxin, tested
InChI	1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key	VQOXZBDYSJBXMA-QEKUPDCNSA-N
mode of action	cell membrane \| interferes
product line	BioReagent
Quality Level	200
shipped in	dry ice
SMILES string	C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)C=CC=CC=CC=CCCC=CC=C[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable

Application:	Nystatin suspension has been used: • to inhibit caveolin-mediated endocytosis • as a component of Eagle′s minimum essential medium (EMEM) • to enumerate lactic acid bacteria (LAB) • in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells. This product is recommended for use in cell culture applications at 24 mL/L.
Biochem/physiol Actions:	Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.
Disclaimer:	This product is stable at 37°C for three days.
General description:	Chemical structure: polyene
Other Notes:	Nystatin suspension available in 20 mL and 100 mL pack size. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Preparation Note:	It is 0.1μ filtered and cell culture tested.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352207

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